Desyrel tablets contain the active ingredient trazodone hydrochloride, a selective serotonin reuptake inhibitor and 5HT2 receptor antagonist. These tablets are available in dosages of 50 mg, 100 mg, 150 mg, and 300 mg for oral administration. Key inactive ingredients include colloidal silicon dioxide, magnesium stearate, and microcrystalline cellulose.

How should I use this medication?

Take this medication by mouth with a glass of water. Take it as directed on the prescription label at the same time every day. Take this medication shortly after a meal or a light snack. Keep taking this medication unless your care team tells you to stop. Stopping it too quickly can cause serious side effects. It can also make your condition worse. A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time. Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medication?

Keep out of the reach of children and pets. Store at room temperature between 15 and 30 degrees C (59 to 86 degrees F). Protect from light. Keep container tightly closed. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -Bleeding—bloody or black, tar-like stools, red or dark brown urine, vomiting blood or brown material that looks like coffee grounds, small, red or purple spots on skin, unusual bleeding or bruising -Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing -Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision -Low sodium level—muscle weakness, fatigue, dizziness, headache, confusion -Prolonged or painful erection -Serotonin syndrome—irritability, confusion, fast or irregular heartbeat, muscle stiffness, twitching muscles, sweating, high fever, seizures, chills, vomiting, diarrhea -Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss -Thoughts of suicide or self-harm, worsening mood, feelings of depression Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Change in sex drive or performance -Constipation -Dizziness -Drowsiness -Dry mouth

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Bipolar disorder -Bleeding disorder -Glaucoma -Heart disease, or previous heart attack -Irregular heartbeat or rhythm -Kidney disease -Liver disease -Low levels of sodium in the blood -Suicidal thoughts, plans, or attempt by you or a family member -An unusual or allergic reaction to trazodone, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breastfeeding

What may interact with this medication?

Do not take this medication with any of the following: -Certain medications for fungal infections, such as fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole -Cisapride -Dronedarone -Linezolid -MAOIs, such as Carbex, Eldepryl, Marplan, Nardil, and Parnate -Mesoridazine -Methylene blue (injected into a vein) -Pimozide -Saquinavir -Thioridazine This medication may also interact with the following: -Alcohol -Antiviral medications for HIV or AIDS -Aspirin and aspirin-like medications -Barbiturates, such as phenobarbital -Certain medications for blood pressure, heart disease, irregular heart beat -Certain medications for mental health conditions -Certain medications for migraine headache, such as almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan -Certain medications for seizures, such as carbamazepine and phenytoin -Certain medications for sleep -Certain medications that treat or prevent blood clots, such as dalteparin, enoxaparin, warfarin -Digoxin -Fentanyl -Lithium -NSAIDS, medications for pain and inflammation, such as ibuprofen or naproxen -Other medications that cause heart rhythm changes -Rasagiline -Supplements, such as St. John's wort, kava kava, valerian -Tramadol -Tryptophan

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse. Because it may take several weeks to see the full effects of this medication, it is important to continue your treatment as prescribed by your care team. Watch for new or worsening thoughts of suicide or depression. This includes sudden changes in mood, behaviors, or thoughts. These changes can happen at any time but are more common in the beginning of treatment or after a change in dose. Call your care team right away if you experience these thoughts or worsening depression. This medication may cause mood and behavior changes, such as anxiety, nervousness, irritability, hostility, restlessness, excitability, hyperactivity, or trouble sleeping. These changes can happen at any time but are more common in the beginning of treatment or after a change in dose. Call your care team right away if you notice any of these symptoms. This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects. This medication may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your care team if the problem does not go away or is severe. Your mouth may get dry. Chewing sugarless gum or sucking hard candy and drinking plenty of water may help. Contact your care team if the problem does not go away or is severe.

What are the most serious risks of this medication?

This medication may increase thoughts of suicide. This may be more common in children, teenagers, and young adults. The risk may increase after first starting the medication and after dose changes. Talk to your care team right away if you have changes in mood and behavior or thoughts of self-harm or suicide.