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EXPAREL is a sterile injectable suspension that contains bupivacaine in liposome form at a concentration of 13.3 mg/mL. It is intended for infiltration or perineural use. This formulation is preservative-free and consists of white to off-white multivesicular liposomes.
How should I use this medication?
This medication is injected into the affected area. It is given by your care team in a hospital or clinic setting. Talk to your care team about the use of this medication in children. While it may be given to children as young as 6 years for selected conditions, precautions do apply.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
This does not apply.
Where should I keep my medication?
This medication is given in a hospital or clinic. It will not be stored at home.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
What side effects may I notice from receiving this medication?
Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -CNS depression—slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, trouble staying awake -Headache, unusual weakness or fatigue, shortness of breath, nausea, vomiting, rapid heartbeat, blue skin or lips, which may be signs of methemoglobinemia -Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing -Increase in blood pressure -Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision -Seizures Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome): -Anxiety, nervousness -Drowsiness -Nausea -Vomiting
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What should I tell my care team before I take this medication?
They need to know if you have any of these conditions: -G6PD deficiency -Heart disease -Kidney disease -Liver disease -Low blood pressure -Lung disease -An unusual or allergic reaction to bupivacaine, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breast-feeding
What may interact with this medication?
-Acetaminophen -Certain antibiotics, such as dapsone, nitrofurantoin, aminosalicylic acid, sulfonamides -Certain medications for seizures, such as phenobarbital, phenytoin, valproic acid -Chloroquine -Cyclophosphamide -Flutamide -Hydroxyurea -Ifosfamide -Metoclopramide -Nitric oxide -Nitroglycerin -Nitroprusside -Nitrous oxide -Other local anesthetics, such as lidocaine, pramoxine, tetracaine -Primaquine -Quinine -Rasburicase -Sulfasalazine
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medication?
Your condition will be monitored carefully while you are receiving this medication. Be careful to avoid injury while the area is numb, and you are not aware of pain. Numbness and loss of movement in the area where the medication was given can last up to 5 days. If you have a procedure in the next 4 days, tell your care team you had this medication. You should not receive similar medications for 96 hours (4 days) from the time this medication was given.
Source: This information is sourced from Elsevier Inc.
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Prescription medications affect individuals differently, and what works for one person may not work for another. Always consult your doctor, pharmacist, or other qualified healthcare provider to ensure the information displayed applies to your personal circumstances. Only a licensed healthcare provider can advise you on what is safe and effective for you.
Keep all medications out of the reach of children, never share your medicine with others, and use each medication only as prescribed. Your reliance on any information provided on this platform is at your own risk.
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