Flexeril contains cyclobenzaprine hydrochloride, a tricyclic amine salt, as its active ingredient. It is available in tablets for oral administration, with dosage strengths of 5 mg, 7.5 mg, and 10 mg. Key inactive ingredients include colloidal silicon dioxide, croscarmellose sodium, lactose, magnesium stearate, and microcrystalline cellulose.

How should I use this medication?

Take this medication by mouth with a glass of water. Take it as directed on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Do not take it more often than directed. Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medication?

Keep out of the reach of children and pets. Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep container tightly closed. Get rid of any unused medication after the expiration date. To get rid of medications that are no longer needed or have expired: -Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location. -If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -CNS depression—slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, trouble staying awake -Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Constipation -Dizziness -Drowsiness -Dry mouth -Fatigue -Nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Heart disease, irregular heartbeat, or previous heart attack -Liver disease -Thyroid problem -An unusual or allergic reaction to cyclobenzaprine, tricyclic antidepressants, lactose, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breastfeeding

What may interact with this medication?

Do not take this medication with any of the following: -MAOIs, such as Carbex, Eldepryl, Marplan, Nardil, and Parnate -Opioid medications for cough -Safinamide This medication may also interact with the following: -Alcohol -Bupropion -Antihistamines for allergy, cough, and cold -Certain medications for anxiety or sleep -Certain medications for bladder problems, such as oxybutynin, tolterodine -Certain medications for depression, such as amitriptyline, fluoxetine, sertraline -Certain medications for Parkinson disease, such as benztropine, trihexyphenidyl -Certain medications for seizures, such as phenobarbital, primidone -Certain medications for stomach problems, such as dicyclomine, hyoscyamine -Certain medications for travel sickness, such as scopolamine -General anesthetics, such as halothane, isoflurane, methoxyflurane, propofol -Ipratropium -Local anesthetics, such as lidocaine, pramoxine, tetracaine -Medications that relax muscles for surgery -Opioid medications for pain -Phenothiazines, such as chlorpromazine, mesoridazine, prochlorperazine, thioridazine -Verapamil

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse. This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects. Taking this medication with other substances that cause drowsiness, such as alcohol, benzodiazepines, or other opioids can cause serious side effects. Give your care team a list of all medications you use. They will tell you how much medication to take. Do not take more medication than directed. Call emergency services if you have problems breathing or staying awake. Your mouth may get dry. Chewing sugarless gum or sucking hard candy and drinking plenty of water may help. Contact your care team if the problem does not go away or is severe.