Marcaine contains bupivacaine hydrochloride, an amide local anesthetic. It is available as an injectable solution for infiltration, perineural, caudal, epidural, or retrobulbar use, with strengths of 2.5 mg, 5 mg, or 7.5 mg of bupivacaine per mL. Key inactive ingredients include sodium chloride and methylparaben. It is designed for use as a local anesthetic.

How should I use this medication?

This medication is injected into the affected area. It is given by your care team in a hospital or clinic setting. Talk to your care team about the use of this medication in children. While it may be given to children as young as 12 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply.

Where should I keep my medication?

This medication is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -CNS depression—slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, trouble staying awake -Headache, unusual weakness or fatigue, shortness of breath, nausea, vomiting, rapid heartbeat, blue skin or lips, which may be signs of methemoglobinemia -Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing -Increase in blood pressure -Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision -Seizures Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome): -Anxiety, nervousness -Drowsiness -Nausea -Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -G6PD deficiency -Heart disease -Kidney disease -Liver disease -Low blood pressure -Lung disease -An unusual or allergic reaction to bupivacaine, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breastfeeding

What may interact with this medication?

-Acetaminophen -Certain antibiotics, such as dapsone, nitrofurantoin, aminosalicylic acid, sulfonamides -Certain medications for seizures, such as phenobarbital, phenytoin, valproic acid -Chloroquine -Cyclophosphamide -Flutamide -Hydroxyurea -Ifosfamide -Metoclopramide -Nitric oxide -Nitroglycerin -Nitroprusside -Nitrous oxide -Other local anesthetics, such as lidocaine, pramoxine, tetracaine -Primaquine -Quinine -Rasburicase -Sulfasalazine

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medication. Be careful to avoid injury while the area is numb, and you are not aware of pain.

What are the most serious risks of this medication?

There is a risk of serious harm or death if a high dose of this medication is used during labor and delivery. Your care team will make sure the correct dose is used. Notify your care team right away if you have a seizure or pain or tightness in the chest, shoulders, arms, or jaw. There is risk of harm if this medication is injected into a vein or artery. Your care team will take pictures during your procedure to make sure the medication is given into the right area. Talk to your care team right away if you have chest pain, confusion, or trouble breathing, speaking, or walking after your procedure.