Taxol contains the active ingredient paclitaxel in the form of a nonpyrogenic injectable solution. It is an antitumor agent and comes in 30 mg, 100 mg, and 300 mg vials designed for intravenous infusion after dilution. Key inactive ingredients include polyoxyl 35 castor oil and dehydrated alcohol.

How should I use this medication?

This medication is injected into a vein. It is given by your care team in a hospital or clinic setting. Talk to your care team about the use of this medication in children. While it may be given to children for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

Keep appointments for follow-up doses. It is important not to miss your dose. Call your care team if you are unable to keep an appointment.

Where should I keep my medication?

This medication is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing -Increase in blood pressure -Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell -Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision -Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing -Painful swelling, warmth, or redness of the skin, blisters or sores at the infusion site -Pain, tingling, or numbness in the hands or feet -Slow heartbeat—dizziness, feeling faint or lightheaded, confusion, trouble breathing, unusual weakness or fatigue -Unusual bruising or bleeding Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Diarrhea -Hair loss -Joint pain -Loss of appetite -Muscle pain -Nausea -Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Heart disease -Liver disease -Low white blood cell levels -An unusual or allergic reaction to paclitaxel, other medications, foods, dyes, or preservatives -If you or your partner are pregnant or trying to get pregnant -Breast-feeding

What may interact with this medication?

Do not take this medication with any of the following: -Live virus vaccines Other medications may affect the way this medication works. Talk with your care team about all of the medications you take. They may suggest changes to your treatment plan to lower the risk of side effects and to make sure your medications work as intended.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medication. You may need blood work while taking this medication. This medication may make you feel generally unwell. This is not uncommon as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your care team tells you to stop. This medication can cause serious allergic reactions. To reduce the risk, your care team may give you other medications to take before receiving this one. Be sure to follow the directions from your care team. This medication may increase your risk of getting an infection. Call your care team for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick. This medication may increase your risk to bruise or bleed. Call your care team if you notice any unusual bleeding. Be careful brushing or flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medication. Talk to your care team if you may be pregnant. Serious birth defects can occur if you take this medication during pregnancy. Talk to your care team before breastfeeding. Changes to your treatment plan may be needed.

What are the most serious risks of this medication?

This medicine can cause a serious and life-threatening allergic reaction. It can happen after your first dose of this medicine or after receiving additional doses even if you did not previously have an allergic reaction. Your healthcare provider will watch you closely for an allergic reaction when you receive this medicine. You should have access to a hospital or clinic while getting this medicine because it can cause serious, life-threatening reactions. This medicine should only be given by a healthcare provider who has experience in the use of cancer drugs. This medicine can lower blood counts, like red blood cells, white blood cells, and platelets. This can become severe enough to require a blood transfusion. You may get more infections or serious infections during your treatment. Your healthcare provider will check your blood counts during your treatment.