Upneeq contains oxymetazoline hydrochloride, an alpha adrenoceptor agonist, in the form of an ophthalmic solution at a concentration of 0.1%. This sterile solution is designed for ophthalmic use and includes inactive ingredients such as calcium chloride, hypromellose, and sodium chloride.

How should I use this medication?

This medication is only for use in the eye. Do not take by mouth. Follow the directions on the prescription label. Wash hands before and after use. Tilt your head back slightly and pull your lower eyelid down with your index finger to form a pouch. Try not to touch the tip of the container to your eye, fingertips, or any other surface. Squeeze the prescribed number of drops into the pouch. Close the eye for a few moments to spread the drops. Do not use your medication more often than directed. Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

Where should I keep my medication?

Keep out of the reach of children and pets. Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep this medication in the original container. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Dry eyes -Eye irritation or itching -Headache

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Diabetes -Glaucoma -Heart disease -High or low blood pressure -History of stroke -Raynaud's phenomenon -Scleroderma -Sjogren's syndrome -Thromboangiitis obliterans -Thyroid disease -Trouble urinating due to an enlarged prostate gland -An unusual or allergic reaction to oxymetazoline, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breast-feeding

What may interact with this medication?

-MAOIs like isocarboxazid, phenelzine, rasagiline, selegiline, and tranylcypromine -Medications to treat blood pressure and heart disease like ace-inhibitors, beta-blockers, calcium-channel blockers, digoxin, and diuretics -Medications to treat enlarged prostate like alfuzosin, doxazosin, prazosin, and terazosin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Tell your care team if your symptoms do not start to get better or if they get worse. Tell your care team right away if you have any change in your vision. To prevent the spread of infection, do not share eye products with anyone else. If you wear contact lenses, ask your care team when you can use your lenses again.