Vaxelis is a vaccine that contains a combination of diphtheria and tetanus toxoids, acellular pertussis antigens, inactivated poliovirus, Haemophilus b conjugate, and hepatitis B surface antigens. It is formulated as a sterile suspension intended for intramuscular injection, with each dose being 0.5 mL. Key inactive ingredients include 319 mcg of aluminum and polysorbate 80. Vaxelis is designed to provide immunization against diseases such as diphtheria, tetanus, pertussis, poliovirus, Haemophilus influenzae type b, and hepatitis B.

How should I use this medication?

This vaccine is injected into a muscle. It is given by your care team. A copy of Vaccine Information Statements will be given before each vaccination. Be sure to read this information carefully each time. This sheet may change often. Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 6 weeks for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

Keep appointments for follow-up doses as directed. It is important not to miss your dose. Call your care team if you are unable to keep an appointment.

Where should I keep my medication?

This vaccine is only given by your care team. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome): -Fatigue -Fever -Irritability -Loss of appetite -Pain, redness, or irritation at injection site -Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Immune system problems -Infection with fever -Neurologic disease -Seizure disorder -Take medications that prevent or treat blood clots -An unusual or allergic reaction to other vaccines, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breastfeeding

What may interact with this medication?

-Medications that lower your chance of fighting an infection, such as adalimumab, anakinra, infliximab, rilonacept -Medications to treat cancer -Steroid medications, such as prednisone or cortisone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team regularly. Report any side effects to your care team right away. This vaccine, like all vaccines, may not fully protect everyone.