Brand name: Xulane. The active ingredients are norelgestromin and ethinyl estradiol, presented in a transdermal system. This drug is a type of contraceptive that delivers these hormones through the skin with a dosage rate of 150 mcg of norelgestromin and 35 mcg of ethinyl estradiol per day. Key inactive ingredients include crospovidone, lauryl lactate, and a polyisobutylene/polybutene adhesive.

How should I use this medication?

This patch is applied to the skin. Follow the directions on the prescription label. Apply to clean, dry, healthy skin on the buttock, abdomen, upper outer arm or upper torso, in a place where it will not be rubbed by tight clothing. Do not use lotions or other cosmetics on the site where the patch will go. Press the patch firmly in place for 10 seconds to ensure good contact with the skin. Change the patch every 7 days on the same day of the week for 3 weeks. You will then have a break from the patch for 1 week, after which you will apply a new patch. Do not use your medication more often than directed. Contact your care team about the use of this medication in children. Special care may be needed. This medication has been used in female children who have started having menstrual periods. A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

You will need to replace your patch once a week as directed. If your patch is lost or falls off, contact your care team for advice. You may need to use another form of birth control if your patch has been off for more than 1 day.

Where should I keep my medication?

Keep out of the reach of children and pets. Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep the patch in its pouch until time of use. Throw away any unused medication after the expiration date. Dispose of used patches properly. Since a used patch may still contain active hormones, fold the patch in half so that it sticks to itself prior to disposal. Throw away in a place where children or pets cannot reach.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain -Gallbladder problems—severe stomach pain, nausea, vomiting, fever -Increase in blood pressure -Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue -New or worsening migraines or headaches -Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision -Unusual vaginal discharge, itching, or odor -Worsening mood, feelings of depression Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Breast pain or tenderness -Dark patches of skin on the face or other sun-exposed areas -Irregular menstrual cycles or spotting -Nausea -Weight gain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have or ever had any of these conditions: -Abnormal vaginal bleeding -Blood clots -Blood vessel disease -Breast, cervical, endometrial, ovarian, liver, or uterine cancer -Diabetes -Gallbladder disease -Having surgery -Heart disease or recent heart attack -High blood pressure -High cholesterol or triglycerides -History of irregular heartbeat or heart valve problems -Kidney disease -Liver disease -Lupus -Migraine headaches -Protein C or S deficiency -Recently had a baby, miscarriage, or abortion -Stroke -Tobacco use -An unusual or allergic reaction to estrogens, progestins, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breastfeeding

What may interact with this medication?

Do not take this medication with the following: -Dasabuvir; ombitasvir; paritaprevir; ritonavir -Ombitasvir; paritaprevir; ritonavir This medication may also interact with the following: -Acetaminophen -Antibiotics or medications for infections, especially rifampin, rifabutin, rifapentine, penicillins, or tetracyclines -Aprepitant or fosaprepitant -Armodafinil -Ascorbic acid (vitamin C) -Barbiturate medications, such as phenobarbital or primidone -Bosentan -Certain antivirals for HIV or hepatitis -Certain medications for cancer treatment -Certain medications for cholesterol -Certain medications for seizures, such as carbamazepine, clobazam, felbamate, lamotrigine, oxcarbazepine, phenytoin, rufinamide, or topiramate -Cyclosporine -Dantrolene -Elagolix -Flibanserin -Grapefruit juice -Lesinurad -Medications for diabetes -Medications to treat fungal infections, such as griseofulvin, miconazole, fluconazole, ketoconazole, itraconazole, posaconazole, or voriconazole -Mifepristone -Mitotane -Modafinil -Morphine -Mycophenolate -St. John's wort -Tamoxifen -Temazepam -Theophylline or aminophylline -Thyroid hormones -Tizanidine -Tranexamic acid -Ulipristal -Warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medication. Use an additional method of contraception during the first cycle that you use this patch. If you have any reason to think you are pregnant, stop using this medication right away and contact your care team. If you are using this medication for hormone related problems, it may take several cycles of use to see improvement in your condition. Smoking tobacco increases the risk of getting a blood clot or having a stroke while you are taking this medication, especially if you are older than 35 years. This medication can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your care team if you feel you are retaining fluid. This medication can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and sunscreen. Do not use sun lamps, tanning beds, or tanning booths. If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye care specialist. Tenderness, swelling, or minor bleeding of the gums may occur. Talk to your dentist if this happens. Brushing and flossing your teeth regularly may reduce the risk of side effects. Visit your dentist on a regular basis. Tell your dentist about any medications you are taking. If you are going to have elective surgery or an MRI, tell your care team that you are using this medication. You may need to remove the patch before the procedure. Using this medication does not protect you or your partner against HIV or other sexually transmitted infections (STIs).

What are the most serious risks of this medication?

Do not use this medicine if your body mass index (BMI) is 30 or more. If you do not know your BMI, ask your health care provider. You may have a higher risk of getting blood clots. Also, your birth control may not work as well and increase your chance of getting pregnant. This medication can increase the risk of serious blood clots, which can cause a heart attack or stroke. This risk increases if you are older than 35 years of age or use tobacco. You are strongly advised not to use tobacco.