Crestor is a brand name for rosuvastatin, present in the form of rosuvastatin calcium, which acts as an HMG CoA-reductase inhibitor. It is formulated as oral tablets available in dosage strengths of 5 mg, 10 mg, 20 mg, and 40 mg. Key inactive ingredients include crospovidone, hypromellose, lactose monohydrate, and magnesium stearate.

How should I use this medication?

Take this medication by mouth with water. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop. Take antacids with aluminum and magnesium hydroxide in them at a different time of day than this medication. Take antacids 2 hours after this medication. Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 7 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, skip it. Take your next dose at the normal time. Do not take extra or 2 doses at the same time to make up for the missed dose.

Where should I keep my medication?

Keep out of the reach of children and pets. Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from moisture. Keep the container tightly closed. Get rid of any unused medication after the expiration date. To get rid of medications that are no longer needed or have expired: -Take the medication to a take-back program. Check with your pharmacy or law enforcement to find a location. -If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix it with cat litter, dirt, coffee grounds, or another unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -High blood sugar (hyperglycemia)—increased thirst or amount of urine, unusual weakness, fatigue, blurry vision -Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness, fatigue -Muscle injury—unusual weakness, fatigue, muscle pain, dark yellow or brown urine, decrease in amount of urine -Redness, blistering, peeling or loosening of the skin, including inside the mouth Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Fatigue -Headache -Nausea -Stomach pain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Diabetes -Frequently drink alcohol -Kidney disease -Liver disease -Muscle pain or cramps -Thyroid disease -An unusual or allergic reaction to rosuvastatin, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breastfeeding

What may interact with this medication?

Do not take this medication with any of the following: -Red yeast rice This medication may also interact with the following: -Alcohol -Antacids containing aluminum and magnesium hydroxide -Colchicine -Cyclosporine -Febuxostat -Fostamatinib -Some medications for cancer, such as capmatinib, darolutamide, enasidenib, regorafenib -Some medications for HIV or hepatitis -Other medications for cholesterol -Tafamidis -Teriflunomide -Warfarin This medication may affect how other medications work, and other medications may affect the way this medication works. Talk with your care team about all the medications you take. They may suggest changes to your treatment plan to lower the risk of side effects and to make sure your medications work as intended.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. You may need blood work done while you are taking this medication. Taking this medication is only part of a total heart healthy program. Ask your care team if there are other changes you can make to improve your overall health. Your care team may tell you to stop taking this medication if you develop muscle problems. If your muscle problems do not go away after stopping this medication, contact your care team. If you are going to need surgery or a procedure, tell your care team that you are taking this medication. This medication may increase blood sugar. The risk may be higher in patients who already have diabetes. Ask your care team what you can do to lower your risk of diabetes while taking this medication. Talk to your care team if you may be pregnant. Serious birth defects can occur if you take this medication during pregnancy. There are benefits and risks to taking medications during pregnancy. Your care team can help you find the option that works for you. Talk to your care team before breastfeeding. Changes to your treatment plan may be needed.