Lupron contains leuprolide acetate, which is a synthetic analog of gonadotropin releasing hormone (GnRH) in the form of a salt. It comes as a sterile, aqueous injection solution with a concentration of 5 mg/mL, intended for subcutaneous administration. Key inactive ingredients include sodium chloride for tonicity adjustment, benzyl alcohol as a preservative, and water for injection. The formulation is designed to have a pH range between 4.0 and 6.0.

How should I use this medication?

This medication is for injection under the skin or into a muscle. You will be taught how to prepare and give this medication. Use exactly as directed. Take your medication at regular intervals. Do not take it more often than directed. It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your care team to get one. A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time. Talk to your care team about the use of this medication in children. While this medication may be prescribed for children as young as 8 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medication?

Keep out of the reach of children and pets. Store below 25 degrees C (77 degrees F). Do not freeze. Protect from light. Get rid of any unused medication after the expiration date. To get rid of medications that are no longer needed or have expired: -Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location. -If you cannot return the medication, ask your pharmacist or care team how to get rid of this medication safely.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded -Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing -High blood sugar (hyperglycemia)—increased thirst or amount of urine, unusual weakness or fatigue, blurry vision -New or worsening seizures -Redness, blistering, peeling, or loosening of the skin, including inside the mouth -Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision -Swelling and pain of the tumor site or lymph nodes Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome): -Change in sex drive or performance -Hot flashes -Joint pain -Pain, redness, or irritation at injection site -Swelling of the ankles, hands, or feet -Unusual weakness or fatigue

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Diabetes -Heart attack -Heart disease -High blood pressure -High cholesterol -Pain or difficulty passing urine -Spinal cord metastasis -Stroke -Tobacco use -An unusual or allergic reaction to leuprolide, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breast-feeding

What may interact with this medication?

Do not take this medication with any of the following: -Chasteberry -Cisapride -Dronedarone -Pimozide -Thioridazine This medication may also interact with the following: -Estrogen or progestin hormones -Herbal or dietary supplements, like black cohosh or DHEA -Other medications that cause heart rhythm changes -Testosterone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. During the first week, your symptoms may get worse, but then will improve as you continue your treatment. You may get hot flashes, increased bone pain, increased difficulty passing urine, or an aggravation of nerve symptoms. Discuss these effects with your care team, some of them may improve with continued use of this medication. Patients may experience a menstrual cycle or spotting during the first 2 months of therapy with this medication. If this continues, contact your care team. This medication may increase blood sugar. The risk may be higher in patients who already have diabetes. Ask your care team what you can do to lower your risk of diabetes while taking this medication.