Movantik contains naloxegol oxalate as its active ingredient, an opioid antagonist. It is available in tablet form for oral use, with dosage strengths of 12.5 mg and 25 mg of naloxegol. Key inactive ingredients include mannitol, microcrystalline cellulose, and croscarmellose sodium in the tablet core, as well as hypromellose and titanium dioxide in the tablet coating.
How should I use this medication?
Take this medication by mouth with a glass of water. Follow the directions on the prescription label. Swallow medication whole. Do not cut or chew this medication. The medication may also be crushed and mixed with 4 ounces of water. Drink immediately after mixing. Take your medication one time each day, on an empty stomach, at least 1 hour before your first meal of the day or 2 hours after the meal. If you are unable to tolerate your dose, inform your care team so that your dose can be adjusted. Do not take additional laxatives except on your care team's advice. Your care team may prescribe other laxatives if your medication does not work well enough after 3 days of treatment. Tell your care team if you stop taking your pain medication. If you stop taking your pain medication, you should also stop taking this medication. Do not take your medication more often than directed. Do not stop taking except on your care team's advice. A special MedGuide will be given to you before each treatment. Be sure to read this information carefully each time. Talk to your care team about the use of this medication in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Where should I keep my medication?
Keep out of the reach of children and pets. This medication can be abused. Keep your medication in a safe place to protect it from theft. Do not share this medication with anyone. Selling or giving away this medication is dangerous and against the law. Follow the directions in the MedGuide. Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medication after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
What side effects may I notice from receiving this medication?
Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -Stomach pain that is severe, does not go away, or gets worse Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Diarrhea -Gas -Headache -Nausea -Stomach pain -Vomiting
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What should I tell my care team before I take this medication?
They need to know if you have any of these conditions: -Cancer or tumor in abdomen, intestine, or stomach -Diverticulitis -History of bowel blockage -Inflammatory bowel disease -Kidney disease -Liver disease -Recent surgery on the stomach or intestine -Stomach or intestine problems -Taking bevacizumab -An unusual or allergic reaction to naloxegol, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breast-feeding
What may interact with this medication?
Do not take this medication with any of the following: -Adagrasib -Certain antiviral medications for HIV or AIDS -Certain medications for fungal infections, such as ketoconazole, itraconazole, posaconazole, voriconazole -Chloramphenicol -Clarithromycin -Dalfopristin; quinupristin -Idelalisib -Mifepristone -Nefazodone -Telithromycin This medication may also interact with the following: -Bevacizumab -Carbamazepine -Diltiazem -Erythromycin -Grapefruit juice -Methylnaltrexone -Naloxone -Naltrexone -Rifampin -St. John's wort -Verapamil
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medication?
Visit your care team for regular check-ups. Tell your care team if your symptoms do not get better or if they get worse. If you develop unusually persistent or worsening abdominal pain, stop taking your medication and seek medical attention. You may have symptoms of opioid withdrawal during treatment with this medication. Symptoms include sweating, chills, diarrhea, stomach pain, anxiety, irritability, and yawning. Tell your care team if you have any of these symptoms. Also, if you take methadone to treat your pain, you may be more likely to have stomach pain and diarrhea compared to people who do not take methadone. If you take too much of this medication, call your care team or go to the nearest emergency room right away.
Source: This information is sourced from Elsevier Inc.
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Prescription medications affect individuals differently, and what works for one person may not work for another. Always consult your doctor, pharmacist, or other qualified healthcare provider to ensure the information displayed applies to your personal circumstances. Only a licensed healthcare provider can advise you on what is safe and effective for you.
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