Multaq contains the active ingredient dronedarone in its hydrochloride form. This medication is available as a tablet for oral administration, each containing 400 mg of dronedarone base. Dronedarone is a benzofuran derivative, and while the drug class or mechanism is not specified, it is intended for oral use.
How should I use this medication?
Take this medication by mouth with a glass of water. Follow the directions on the prescription label. Take one tablet with the morning meal and one tablet with the evening meal. Do not take your medication more often than directed. Do not stop taking except on the advice of your care team. A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time. Talk to your care team about the use of this medication in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Where should I keep my medication?
Keep out of the reach of children. Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medication after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
What side effects may I notice from receiving this medication?
Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -Slow heartbeat—dizziness, feeling faint or lightheaded, confusion, trouble breathing, unusual weakness or fatigue -Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue -Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing -Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet -Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue -Lung injury—shortness of breath or trouble breathing, cough, spitting up blood, chest pain, fever Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Diarrhea -Nausea -Stomach pain -Vomiting
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What should I tell my care team before I take this medication?
They need to know if you have any of these conditions: -Heart failure -History of stroke -Irregular heartbeat or rhythm other than atrial fibrillation (AFib) -Liver disease -Lung disease -Low levels of magnesium in the blood -Low levels of potassium in the blood -Other heart conditions, such as heart block -Pacemaker -Permanent atrial fibrillation (AFib) -Slow heartbeat -An unusual or allergic reaction to dronedarone, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breastfeeding
What may interact with this medication?
Do not take this medication with any of the following: -Adagrasib -Arsenic trioxide -Certain antibiotics, such as clarithromycin, erythromycin, pentamidine, telithromycin, troleandomycin -Certain medications for depression, such as tricyclic antidepressants -Certain medications for fungal infections, such as fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole -Certain medications for irregular heart beat, such as amiodarone, disopyramide, flecainide, ibutilide, quinidine, propafenone, sotalol -Certain medications for malaria, such as chloroquine, halofantrine -Cisapride -Cyclosporine -Droperidol -Haloperidol -Methadone -Nefazodone -Other medications that cause heart rhythm changes, such as degarelix, encorafenib, entrectinib, eribulin, goserelin, lapatinib -Phenothiazines, such as chlorpromazine, mesoridazine, prochlorperazine, thioridazine -Pimozide -Ritonavir -Ziprasidone This medication may also interact with the following: -Certain medications for blood pressure, heart disease, or irregular heart beat, such as diltiazem, metoprolol, propranolol, verapamil -Certain medications for cholesterol, such as atorvastatin, lovastatin, simvastatin -Certain medications for seizures, such as carbamazepine, phenobarbital, phenytoin -Dabigatran -Digoxin -Dofetilide -Grapefruit juice -Rifampin -Sirolimus -St. John's wort -Tacrolimus -Warfarin
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medication?
Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse. This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Talk to your care team if you may be pregnant. Serious birth defects can occur if you take this medication during pregnancy and for 5 days after the last dose. You will need a negative pregnancy test before starting this medication. Contraception is recommended while taking this medication and for 5 days after the last dose. You care team can help you find the option that works for you. Do not breastfeed while taking this medication and for 5 days after the last dose.
What are the most serious risks of this medication?
Do not take this medicine if you have symptoms of heart failure that recently worsened and you were hospitalized or if you have severe heart failure. Do not take this medicine if you have permanent atrial fibrillation. Your healthcare provider will monitor your heart rhythm while you are taking this medicine to make sure it is a normal rhythm.
Source: This information is sourced from Elsevier Inc.
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