Polytrim is an ophthalmic solution containing Polymyxin B sulfate and Trimethoprim. It is an antimicrobial drug used for topical application to the eyes and comes in a solution form with 10,000 units of Polymyxin B per mL and 1 mg of Trimethoprim per mL. Key inactive ingredients include benzalkonium chloride, water for injection, and sodium chloride.

How should I use this medication?

This medication is only for use in the eye. Follow the directions on the prescription label. Wash your hands before and after use. Tilt your head back slightly and pull your lower eyelid down with your index finger to form a pouch. Try not to touch the tip of the dropper or tube to your eye, fingertips, or other surfaces. Squeeze the prescribed number of drops into the pouch. Close the eye gently to spread the drops. Do not use your medication more often than directed. Finish the full course of medication prescribed by your care team even if you think your condition is better. Do not stop using except on the advice of your care team. Talk to your care team about the use of this medication in children. While this medication may be prescribed for children as young as 2 months for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

Where should I keep my medication?

Keep out of the reach of children. Store at room temperature 15 to 25 degrees C (59 to 77 degrees F). Protect from light. To prevent the spread of infection, it is best to throw away any unused eye drops after you finish the course of treatment. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -New or worsening eye pain, redness, irritation, or discharge Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Eye irritation or itching -Increased tears after use

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Wear contact lenses -An unusual or allergic reaction to polymyxin B, trimethoprim, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breast-feeding

What may interact with this medication?

Interactions are not expected. Do not use any other eye products without advice of your care team.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Check with your care team if your condition does not get better after 5 days, or if it gets worse. If you wear contact lenses, ask when you can use your lenses again. A burning or stinging reaction that does not go away may mean you are allergic to this product. Stop use and call your care team. To prevent the spread of infection, do not share eye products or other personal items with anyone else.