Reclast contains zoledronic acid monohydrate, an inhibitor of osteoclastic bone resorption in the bisphosphonate class. It is formulated as a sterile solution available in 100 mL bags for intravenous infusion, with each bag containing 5 mg of zoledronic acid. Key inactive ingredients include mannitol and sodium citrate. The solution is intended for infusion, with a pH of approximately 6.0 to 7.0.

How should I use this medication?

This medication is injected into a vein. It is given by your care team in a hospital or clinic setting. A special MedGuide will be given to you before each treatment. Be sure to read this information carefully each time. Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

Keep appointments for follow-up doses. It is important not to miss your dose. Call your care team if you are unable to keep an appointment.

Where should I keep my medication?

This medication is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet -Low calcium level—muscle pain or cramps, confusion, tingling, or numbness in the hands or feet -Osteonecrosis of the jaw—pain, swelling, or redness in the mouth, numbness of the jaw, poor healing after dental work, unusual discharge from the mouth, visible bones in the mouth -Severe bone, joint, or muscle pain Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Diarrhea -Dizziness -Headache -Nausea -Stomach pain -Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Bleeding disorder -Cancer -Dental disease -Kidney disease -Low levels of calcium in the blood -Low red blood cell counts -Lung or breathing disease, such as asthma -Receiving steroids, such as dexamethasone or prednisone -An unusual or allergic reaction to zoledronic acid, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breast-feeding

What may interact with this medication?

-Certain antibiotics given by injection -Medications for pain and inflammation, such as ibuprofen, naproxen, NSAIDs -Some diuretics, such as bumetanide, furosemide -Teriparatide

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. It may be some time before you see the benefit from this medication. Some people who take this medication have severe bone, joint, or muscle pain. This medication may also increase your risk for jaw problems or a broken thigh bone. Tell your care team right away if you have severe pain in your jaw, bones, joints, or muscles. Tell your care team if you have any pain that does not go away or that gets worse. You should make sure you get enough calcium and vitamin D while you are taking this medication. Discuss the foods you eat and the vitamins you take with your care team. You may need bloodwork while taking this medication. Tell your dentist and dental surgeon that you are taking this medication. You should not have major dental surgery while on this medication. See your dentist to have a dental exam and fix any dental problems before starting this medication. Take good care of your teeth while on this medication. Make sure you see your dentist for regular follow-up appointments.