RHOFADE is a brand of pharmaceutical cream that contains oxymetazoline hydrochloride, an alpha adrenoceptor agonist, as its active ingredient. The formulation is a 1% cream intended for topical use, with key inactive ingredients including sodium citrate dihydrate, citric acid anhydrous, and disodium edetate dihydrate. The cream is designed as a topical treatment, commonly used to alleviate symptoms associated with redness or swelling, based on its drug class.

How should I use this medication?

This medication is for external use only. Do not take by mouth. Wash your hands before and after use. Do not get it in your eyes. If you do, rinse your eyes with plenty of cool tap water. Use it as directed on the prescription label at the same time every day. Do not use it more often than directed. Keep taking it unless your care team tells you to stop. Apply a thin film of the medication to the affected area. If you are using other topical medications, apply them at different times of the day. Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

Where should I keep my medication?

Keep out of the reach of children and pets. Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medication after the expiration date. To get rid of medications that are no longer needed or have expired: -Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location. -If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage. If you are not sure, ask your care team. If it is safe to put in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome): -Irritation at application site

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Diabetes -Glaucoma -Heart disease -High or low blood pressure -History of stroke -Raynaud's phenomenon -Scleroderma -Sjogren's syndrome -Thromboangiitis obliterans -Thyroid disease -Trouble urinating due to an enlarged prostate gland -An unusual or allergic reaction to oxymetazoline, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breast-feeding

What may interact with this medication?

This medication may interact with the following: -Certain medications to treat an enlarged prostate, such as alfuzosin, doxazosin, prazosin, and terazosin -Certain medications to treat blood pressure and heart disease, such as ace-inhibitors, beta-blockers, calcium-channel blockers, digoxin, and diuretics -MAOIs, such as isocarboxazid, phenelzine, rasagiline, selegiline, and tranylcypromine

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse. This medication can make certain skin conditions worse. Only use it for conditions for which your care team has prescribed. Do not get this medication in your eyes or on your lips. If you do, rinse out with plenty of cool tap water.