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Vivitrol contains naltrexone base anhydrous and is an opioid antagonist with little or no opioid agonist activity. It is formulated as an extended-release injectable suspension and administered by deep intramuscular injection by a healthcare provider. Vivitrol is available in a dosage strength of 380 mg per vial. Key inactive ingredients include a biodegradable matrix of polylactide-co-glycolide, carboxymethylcellulose sodium, polysorbate 20, and sodium chloride.
How should I use this medication?
The medication is injected into a muscle. It is given by your care team in a hospital or clinic setting. A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time. Talk to your care team about the use of this medication in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
It is important not to miss your dose. Call your care team if you are unable to keep an appointment.
Where should I keep my medication?
This medication is given in a hospital or clinic. It will not be stored at home.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
What side effects may I notice from receiving this medication?
Side effects that you should report to your care team as soon as possible: -Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing -Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue -Thoughts of suicide or self-harm, worsening mood, feelings of depression -Trouble breathing Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Dizziness -Drowsiness -Loss of appetite -Muscle pain or cramps -Nausea -Pain, redness, or irritation at injection site -Vomiting
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What should I tell my care team before I take this medication?
They need to know if you have any of these conditions: -Bleeding disorder -Frequently drink alcohol -Kidney disease -Liver disease -Low platelet levels -Substance use disorder -Take medications that treat or prevent blood clots -An unusual or allergic reaction to naltrexone, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breast-feeding
What may interact with this medication?
Do not take this medication with any of the following: -Medications for pain, such as pentazocine, buprenorphine, butorphanol, nalbuphine, oxycodone, morphine
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medication?
Your condition will be monitored carefully while you are receiving this medication. Visit your care team regularly. For this medication to be effective, you should attend any counseling or support groups that your care team recommends. Do not try to overcome the effects of the medication by taking large amounts of opioids. This can cause severe problems, including death. Also, you may be more sensitive to lower doses of opioids after you stop taking this medication. If you are going to have surgery or another procedure, tell your care team that you are using this medication. Do not treat yourself for coughs, colds, pain, or diarrhea. Ask your care team for advice. Some ingredients may interact with this medication and cause side effects. Wear a medical ID bracelet or chain. Carry a card that describes your condition. List the medications and doses you take on the card. This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.
Source: This information is sourced from Elsevier Inc.
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Prescription medications affect individuals differently, and what works for one person may not work for another. Always consult your doctor, pharmacist, or other qualified healthcare provider to ensure the information displayed applies to your personal circumstances. Only a licensed healthcare provider can advise you on what is safe and effective for you.
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