Zyvox is a brand name for linezolid, a synthetic antibacterial agent from the oxazolidinone class. It is formulated as a ready-to-use sterile isotonic solution for intravenous infusion, with each milliliter containing 2 mg of linezolid. The inactive ingredients in this formulation include dextrose monohydrate, sodium citrate dihydrate, and citric acid anhydrous.

How should I use this medication?

Take this medication by mouth. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Take all of this medication unless your care team tells you to stop it early. Keep taking it even if you think you are better. Talk to your care team about the use of this medication in children. While it may be prescribed for children for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medication?

Keep out of the reach of children and pets. Store at room temperature at 25 degrees C (77 degrees F). Protect from light and moisture. Keep the container tightly closed. Get rid of any unused medication after the expiration date. To get rid of medications that are no longer needed or have expired: -Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location. -If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -Change in vision -High lactic acid level—muscle pain or cramps, stomach pain, trouble breathing, general discomfort and fatigue -Infection—fever, chills, cough, or sore throat -Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue -Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing -Low sodium level—muscle weakness, fatigue, dizziness, headache, confusion -Muscle injury—unusual weakness or fatigue, muscle pain, dark yellow or brown urine, decrease in amount of urine -Pain, tingling, or numbness in the hands or feet -Seizures -Severe diarrhea, fever -Unusual bruising or bleeding -Unusual vaginal discharge, itching, or odor Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome): -Diarrhea -Headache -Nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Diabetes -High blood pressure -Low platelet levels -Low levels of sodium in the blood -Low red blood cell levels -Low white blood cell levels -Pheochromocytoma -Seizures -Stomach or intestine problems, such as colitis -Thyroid disease -An unusual or allergic reaction to linezolid, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breast-feeding

What may interact with this medication?

Do not take this medication with any of the following: -Certain medications for depression, anxiety, or other mental health conditions -Codeine -Dihydrocodeine -Fenfluramine -MAOIs, such as Marplan, Nardil, and Parnate -Meperidine -Methyldopa -Morphine -Ozanimod -Procarbazine -St. John's wort -Stimulant medications for ADHD, weight loss, or staying awake -Tapentadol -Tramadol This medication may also interact with the following: -Certain medications for blood pressure, heart disease, irregular heartbeat -Certain medications for migraine headache, such as almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan -Estrogen or progestin hormones -Other opioid medications for pain -Phenylpropanolamine -Pseudoephedrine

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Tell your care team if your symptoms do not start to get better or if they get worse. Do not treat diarrhea with over the counter products. Contact your care team if you have diarrhea that lasts more than 2 days or if it is severe and watery. You may need to be on a special diet while you are taking this medication. Ask your care team.