Prilosec contains the active ingredient omeprazole in the form of delayed-release capsules. Omeprazole is a substituted benzimidazole that acts to inhibit gastric acid secretion. The capsules are available in 10 mg, 20 mg, and 40 mg strengths and are administered orally. Key inactive ingredients include glyceryl monostearate, hypromellose, and titanium dioxide.

How should I use this medication?

Take this medication by mouth with a glass of water. Take it as directed on the label at the same time every day. Do not cut, crush, or chew this medication. Swallow the capsules whole. You may open the capsule and put the contents in 1 tablespoon of applesauce. Swallow the medication and applesauce right away. Do not chew the medication or applesauce. Take this medication before a meal. Keep taking it unless your care team tells you to stop. Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 2 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medication?

Keep out of the reach of children and pets. Store between 15 and 30 degrees C (59 and 86 degrees F). Protect from light and moisture. Get rid of any unused medication after the expiration date. To get rid of medications that are no longer needed or expired: -Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location. -If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet -Low magnesium level—muscle pain or cramps, unusual weakness, fatigue, fast or irregular heartbeat, tremors -Low vitamin B12 level—pain, tingling, or numbness in the hands or feet, muscle weakness, dizziness, confusion, difficulty concentrating -Rash on the cheeks or arms that gets worse in the sun -Redness, blistering, peeling, or loosening of the skin, including inside the mouth -Severe diarrhea, fever -Unusual bleeding or bruising Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Gas -Headache -Nausea -Stomach pain -Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Liver disease -Low levels of calcium, magnesium, or potassium in the blood -Lupus -An unusual or allergic reaction to omeprazole, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breastfeeding

What may interact with this medication?

Do not take this medication with any of the following: -Atazanavir -Clopidogrel -Nelfinavir -Rilpivirine This medication may also interact with the following: -Antifungals, such as itraconazole, ketoconazole, voriconazole -Certain antivirals for HIV or hepatitis -Certain medications that treat or prevent blood clots, such as warfarin -Cilostazol -Citalopram -Cyclosporine -Dasatinib -Digoxin -Disulfiram -Diuretics -Erlotinib -Iron supplements -Medications for anxiety, panic, and sleep, such as diazepam -Medications for seizures, such as carbamazepine, phenobarbital, phenytoin -Methotrexate -Mycophenolate mofetil -Nilotinib -Rifampin -St. John's wort -Tacrolimus -Vitamin B12

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. It can take several days before your stomach pain gets better. Tell your care team if your symptoms do not start to get better or if they get worse. Do not treat diarrhea with over the counter products. Contact your care team if you have diarrhea that lasts more than 2 days or if it is severe and watery. You may need blood work while taking this medication. Using this medication for a long time may weaken your bones. The risk of bone fractures may be increased. Talk to your care team about your bone health. Using this medication for a long time may cause growths (polyps) in the stomach. They usually don't cause any symptoms. They are usually not cancerous. Contact your care team if you notice pain or tenderness when you press your stomach, have nausea, or see bloody or black, tar-like stools. This medication may cause a decrease in vitamin B12. You should make sure that you get enough vitamin B12 while you are taking this medication. Discuss the foods you eat and the vitamins you take with your care team.