VYZULTA is a medication containing the active ingredient latanoprostene bunod, formulated as an ophthalmic solution. It is a prostaglandin analog intended for topical use in the eyes. The solution includes a small amount of the preservative benzalkonium chloride and other inactive ingredients like polysorbate 80 and glycerin. VYZULTA is commonly used to manage conditions related to eye pressure by leveraging its prostaglandin analog properties.

How should I use this medication?

This medication is only for use in the eye. Do not take by mouth. Follow the directions on the prescription label. Wash hands before and after use. Tilt the head back slightly and pull down the lower lid with the index finger to form a pouch. Try not to touch the tip of the dropper to your eye or into the pouch. Squeeze the prescribed number of drops into the pouch and gently close the eyes for 1 to 2 minutes. Do not blink. Use your doses at regular intervals. Do not use you medication more often than directed. If you are using another eye product, wait at least 5 minutes between use of this medication and the other eye product. Talk to your care team about the use of this medication in children. While this medication may be prescribed for children as young as 17 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

Where should I keep my medication?

Keep out of the reach of children and pets. Store unopened bottle in the refrigerator at 2 to 8 degrees C (36 to 46 degrees F). Once opened, the container may be stored at room temperature up to 25 degrees C (77 degrees F) for up to 8 weeks. Protect from light. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -Change in vision -New or worsening eye pain, redness, irritation, or discharge Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Change in eye, eyelash, or eyelid color -Eye irritation or itching -Increase in length, thickness, or number of eyelashes

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Eye disease, vision problems -Eye injury, infection, or swelling -Wear contact lenses -An unusual or allergic reaction to latanoprostene bunod, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breast-feeding

What may interact with this medication?

Interactions are not expected. Do not use any other eye products without telling your care team.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Report any serious side effects right away. Stop using this medication if your eyes get swollen, painful, or have a discharge, and see your care team as soon as you can. This medication may cause your eye, eyelashes, and eyelids to change color. Tell your care team if this happens. If only one eye is being treated with this medication, a difference may develop between the treated and untreated eye in eyelash length, darkness or thickness, and/or color changes of the eyelid skin or iris. These changes may be permanent. If you wear contact lenses, take them out before placing drops in the eye. Contact lenses may be put back in 15 minutes after putting the drops in your eyes.