Bumex contains the active ingredient bumetanide, which is a loop diuretic. It is formulated as tablets available in strengths of 0.5 mg, 1 mg, and 2 mg for oral administration. Key inactive ingredients include lactose anhydrous, magnesium stearate, and microcrystalline cellulose.

How should I use this medication?

Take this medication by mouth. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop. Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medication?

Keep out of the reach of children and pets. Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain -Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine -Hearing loss, ringing in ears -Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet -Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision -Low potassium level—muscle pain or cramps, unusual weakness or fatigue, fast or irregular heartbeat, constipation -Unusual bruising or bleeding Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Burning or tingling sensation in hands or feet -Constipation -Diarrhea -Headache -Nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Dehydration -Diarrhea -Irregular heartbeat or rhythm -Kidney problems -Liver disease -Low levels of electrolytes, like magnesium, potassium, or sodium, in your blood -Vomiting -An unusual or allergic reaction to bumetanide, sulfa medications, other medications, foods, dyes or preservatives -Pregnant or trying to get pregnant -Breast-feeding

What may interact with this medication?

This medication may interact with the following: -Alcohol -Certain antibiotics given by injection -Diuretics -Heart medications like digoxin and dofetilide -Hormones like cortisone, fludrocortisone, hydrocortisone -Lithium -Medications for diabetes -Medications for high blood pressure -Medications for inflammation like indomethacin -OTC supplements like ginseng and ephedra

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Check your blood pressure as directed. Ask your care team what your blood pressure should be. Also, find out when you should contact them. You may need to be on a special diet while you are taking this medication. Ask your care team. Also, find out how many glasses of fluids you need to drink each day. Check with your care team if you have severe diarrhea, nausea, and vomiting, or if you sweat a lot. The loss of too much body fluid may make it dangerous for you to take this medication. Be careful brushing or flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medication. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand up or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Do not treat yourself for coughs, colds, or pain while you are using this medication without asking your care team for advice. Some medications may increase your blood pressure.

What are the most serious risks of this medication?

This medicine is a strong diuretic (or water pill) and can cause you to become dehydrated. Your healthcare provider will monitor you to make sure you are receiving the right amount of medicine.