Zestril contains the active ingredient lisinopril, a synthetic peptide derivative that acts as an angiotensin converting enzyme (ACE) inhibitor. It is available in tablet form with dosage strengths of 2.5 mg, 5 mg, 10 mg, 20 mg, 30 mg, and 40 mg, intended for oral administration. Key inactive ingredients include colloidal silicon dioxide, dibasic calcium phosphate, magnesium stearate, mannitol, and pre-gelatinized starch.

How should I use this medication?

Take this medication by mouth. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop. Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 6 for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medication?

Keep out of the reach of children and pets. Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from moisture. Keep the container tightly closed. Do not freeze. Avoid exposure to extreme heat. Get rid of any unused medication after the expiration date. To get rid of medications that are no longer needed or have expired: -Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location. -If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions or angioedema—skin rash, itching, hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing -High potassium level—muscle weakness, fast or irregular heartbeat -Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet -Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness, fatigue -Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Cough -Dizziness -Headache

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Diabetes -Heart or blood vessel disease -History of swelling of the tongue, face, or lips with difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat (angioedema) -Kidney disease -Low blood pressure -An unusual or allergic reaction to lisinopril, insect venom, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breastfeeding

What may interact with this medication?

Do not take this medication with any of the following: -Hymenoptera venom -Sacubitril; valsartan This medication may also interact with the following: -Aliskiren -Angiotensin receptor blockers, such as losartan or valsartan -Certain medications for diabetes -Diuretics -Everolimus -Gold compounds -Lithium -NSAIDs, medications for pain and inflammation, such as ibuprofen or naproxen -Potassium salts or supplements -Salt substitutes -Sirolimus -Temsirolimus

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Check your blood pressure as directed. Know what your blood pressure should be and when to contact your care team. Do not treat yourself for coughs, colds, or pain while you are using this medication without asking your care team for advice. Some medications may increase your blood pressure. Talk to your care team if you may be pregnant. Serious birth defects can occur if you take this medication during pregnancy. This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects. Avoid salt substitutes unless you are told otherwise by your care team.

What are the most serious risks of this medication?

Do not take this medication if you may be pregnant. Serious fetal side effects may occur. Talk to your care team right away if you are or think you may be pregnant. Your care team can help you find the treatment option that works for you.