Inspra contains eplerenone as the active ingredient, which blocks aldosterone binding at the mineralocorticoid receptor. It comes in tablet form for oral administration in 25 mg or 50 mg strengths. Key inactive ingredients include colloidal silicone dioxide, croscarmellose sodium, and lactose monohydrate.

How should I use this medication?

Take this medication by mouth. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop. Do not take this medication with grapefruit juice. Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medication?

Keep out of the reach of children and pets. Store at room temperature at 25 degrees C (77 degrees F). Get rid of any unused medication after the expiration date. To get rid of medications that are no longer needed or have expired: -Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location. -If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put into the trash, take the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -High potassium level—muscle weakness, fast or irregular heartbeat -Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Breast pain or tenderness -Change in sex drive or performance -Dizziness -Headache -Irregular menstrual cycles or spotting -Unexpected breast tissue growth

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Addison's disease or low adrenal gland function -Diabetes (high blood sugar) -High levels of potassium in the blood -If you are on a special diet, such as a low-salt diet and are using dietary salt substitutes -Kidney disease -Liver disease -An unusual or allergic reaction to eplerenone, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breast-feeding

What may interact with this medication?

Do not take this medication with any of the following: -Adagrasib -Boceprevir -Ceritinib -Certain antibiotics, such as chloramphenicol, clarithromycin, dalfopristin;quinupristin, telithromycin -Certain diuretics, such as amiloride, spironolactone, triamterene -Certain medications for fungal infections, such as itraconazole, ketoconazole, posaconazole, voriconazole -Certain medications for HIV or AIDS, such as atazanavir, cobicistat, darunavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir boosted with ritonavir, tipranavir -Grapefruit and grapefruit juice -Ibritumomab tiuxetan -Idelalisib -Lonafarnib -Mifepristone -Nefazodone -Potassium salts or supplements -Ribociclib -Tucatinib This medication may also interact with the following: -Certain medications for high blood pressure, such as enalapril, candesartan, lisinopril, valsartan -Erythromycin -Fluconazole -Lithium -NSAIDs, medications for pain and inflammation, such as ibuprofen or naproxen -Verapamil

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Check your blood pressure as directed. Ask your care team what your blood pressure should be. Also, find out when you should contact them. Do not treat yourself for coughs, colds, or pain while you are using this medication without asking your care team for advice. Some medications may increase your blood pressure. Check with your care team if you have severe diarrhea, nausea, and vomiting, or if you sweat a lot. The loss of too much body fluid may make it dangerous for you to take this medication. You may need to be on a special diet while taking this medication. Ask your care team. Also, find out how many glasses of fluid you need to drink each day. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effects of this medication. Avoid alcoholic drinks. Avoid salt substitutes unless you are told otherwise by your care team.