Diuril is a brand name for the active ingredient chlorothiazide sodium, a diuretic and antihypertensive medication. It is formulated as a sterile powder for injection, with each vial containing 500 mg of chlorothiazide sodium. The formulation includes mannitol and sodium hydroxide as inactive ingredients. Diuril is intended to help remove excess fluid from the body and reduce high blood pressure.

How should I use this medication?

This medication is injected into a vein. This medication is given in a hospital or clinic. Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply. This medication is not for regular use.

Where should I keep my medication?

This medication is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine -Gout—severe pain, redness, warmth, or swelling in joints, such as the big toe -Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet -Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision -Low potassium level—muscle pain or cramps, unusual weakness or fatigue, fast or irregular heartbeat, constipation -Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Change in sex drive or performance -Headache -Upset stomach

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Diabetes -Kidney disease -Liver disease -Small amount of urine or difficulty passing urine -Systemic lupus erythematosus -An unusual or allergic reaction to chlorothiazide, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breast-feeding

What may interact with this medication?

This medication may interact with the following: -Barbiturates like phenobarbital -Lithium -Medications for diabetes -Medications for high blood pressure -NSAIDs like ibuprofen -Prescription pain medications -Skeletal muscle relaxants like tubocurarine -Some cholesterol-lowering medications like cholestyramine or colestipol -Steroid medications like prednisone or cortisone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Check your blood pressure as directed. Ask your care team what your blood pressure should be and when you should contact them. You may need to be on a special diet while taking this medication. Ask your care team. Check with your care team if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medication. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medication. Avoid alcoholic drinks. This medication may increase blood sugar. Ask your care team if changes in diet or medications are needed if you have diabetes. This medication can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.