The brand name is Tarka. This medication contains two active ingredients: verapamil hydrochloride, a calcium channel blocker in a slow-release form, and trandolapril, an angiotensin converting enzyme inhibitor in an immediate-release form. Tarka is formulated as an extended-release tablet.

How should I use this medication?

Take this medication by mouth. Take it as directed on the prescription label at the same time every day. Take it with food. Keep taking it unless your care team tells you to stop. Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medication?

Keep out of the reach of children and pets. Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible: -allergic reactions like skin rash or hives, swelling of the hands, feet, face, lips, throat, or tongue -decreased amount of urine passed -difficulty breathing, or swallowing -persistent dry cough -redness, blistering, peeling or loosening of the skin, including inside the mouth -stomach pain -swelling of your legs and ankles -irregular or fast heartbeat, chest pain, palpitations Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): -decreased sexual function or desire -drowsiness or dizziness -facial flushing -headache

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Bone marrow disease -Collagen-vascular disease like scleroderma -Heart or blood vessel disease -If you are on a special diet, such as a low-salt diet -Immune system disease like lupus -Kidney or liver disease -Low blood pressure -Previous swelling of the tongue, face, or lips with difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat -Slow or irregular heartbeat -An unusual or allergic reaction to trandolapril, verapamil, other medications, insect venom, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breast-feeding

What may interact with this medication?

Do not take this medication with any of the following: -Cisapride -Disopyramide -Dofetilide -Flibanserin -Lomitapide -Sacubitril; valsartan -Tranylcypromine This medication may also interact with the following: -Aliskiren -Almotriptan -Buspirone -Carbamazepine -Certain medications for blood pressure, heart disease, irregular heart beat -Certain medications for cholesterol like atorvastatin, lovastatin, simvastatin -Certain medications for diabetes like glyburide -Cimetidine -Colchicine -Diuretics -Doxorubicin -Gold -Imipramine -Lithium -Local anesthetics or general anesthetics -Medications for infection like clarithromycin, erythromycin, rifampin, telithromycin -Medications that lower your chance of fighting infection -Medications that relax muscles for surgery -NSAIDs, medications for pain and inflammation, like ibuprofen or naproxen -Phenobarbital -Potassium salts or potassium supplements -Ritonavir -St. John's Wort -Sulfinpyrazone -Theophylline

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Check your blood pressure as directed. Ask your care team what your blood pressure should be and when you should contact them. Call your care team if you notice an irregular or fast heart beat. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks. Women should inform their care team if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your care team or pharmacist for more information. Check with your care team if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medication. Avoid salt substitutes unless you are told otherwise by your care team. Do not treat yourself for coughs, colds, or pain while you are taking this medication without asking your care team for advice. Some ingredients may increase your blood pressure. This medication can sometimes cause dental problems for some patients. Clean and floss your teeth carefully and regularly. Check with your dentist if your gums get swollen or inflamed and have the dentist clean your teeth regularly.